4/12/2023 0 Comments Spindle assembly checkpoint![]() identified germline mutations in BUB1 and BUB3, components of the spindle assembly checkpoint (SAC) and thus controllers of correct chromosome segregation, as cause for CRC predisposition. īased on genome-wide copy number profiling and exome sequencing in early-onset and familial CRC, De Voer et al. Despite the identification of novel candidate genes for CRC predisposition, overall, they account for a very low number of familial cases, and for many of the suggested genes, identification of additional mutated families is essential to conclusively define their actual implication in CRC predisposition. Genome-wide genetic and genomic screenings have tried to identify novel high penetrance genes for CRC. Much of the heritability associated with colorectal cancer (CRC) cannot be explained by the currently known genetic risk factors for CRC. As of today, the rarity of functionally relevant mutations identified in familial and/or early onset series does not support the inclusion of BUB1 and BUB3 testing in routine genetic diagnostics of familial CRC. BUB1 c.2473C>T (p.P825S) and BUB3 c.77C>T (p.T26I) remained as variants of uncertain significance. Evident functional effects in the heterozygous form were observed for c.1965-1G>A, but not for c.2296G>A (p.E766K), in spite of the positive co-segregation in the family. Neither variegated aneuploidy nor dysmorphic traits were observed in carriers. Four novel or rare germline variants, one splice-site and three missense, were identified in four families. We performed a mutational analysis of BUB1 and BUB3 in 456 uncharacterized mismatch repair-proficient hereditary non-polyposis CRC families and 88 polyposis cases. Germline mutations in BUB1 and BUB3 have been reported to increase the risk of developing colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic variegated aneuploidy syndrome.
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![]() There may also be urgency for bowel movements, a feeling of incomplete evacuation ( tenesmus), bloating or abdominal distention. The primary symptoms of IBS are abdominal pain or discomfort in association with frequent diarrhea and/or constipation, a change in bowel habits. 3 Medical conditions that accompany IBS. ![]() The most common theory is that IBS is a disorder of the interaction between the brain and the gastrointestinal tract, although there may also be abnormalities in the gut flora or the immune system. In IBS, routine clinical tests yield no abnormalities, though the bowels may be more sensitive to certain stimuli, such as balloon insufflation testing. Several conditions may present as IBS including celiac disease, mild infections, parasitic infections like giardiasis, several inflammatory bowel diseases, functional chronic constipation and chronic functional abdominal pain. Patient education and a good doctor-patient relationship are also important. Other functional or pain disorders and certain psychological conditions are more common in those with IBS.Īlthough there is no cure for IBS, there are treatments which attempt to relieve symptoms, including dietary adjustments, medication and psychological interventions. IBS may begin after an infection (post-infectious, IBS-PI) or a stressful life event. Diarrhea or constipation may predominate, or they may alternate (classified as IBS-D, IBS-C or IBS-A, respectively). In some cases, the symptoms are relieved by bowel movements. In gastro psychology and gastroenterology, irritable bowel syndrome ( IBS) is a functional bowel disorder characterized by mild to severe abdominal pain, discomfort, bloating and alteration of bowel habits. See Psychological aspects of irritable bowel syndrome Irritable bowel syndrome synonymous with GILL/HT/IB 4/11/2023 0 Comments Define sentience![]() Sponges, placozoans, and mesozoans, with simple body plans and no nervous system, are the only members of the animal kingdom that possess no consciousness. Accordingly, only organisms that possess these substrates, all within the animal kingdom, are said to be conscious. Regarding animal consciousness, according to the Cambridge Declaration of Consciousness, which was publicly proclaimed on 7 July 2012 at Cambridge University, consciousness is that which requires specialized neural structures, chiefly neuroanatomical, neurochemical, and neurophysiological substrates, which manifests in more complex organisms as the central nervous system, to exhibit consciousness. Other philosophers, such as Daniel Dennett, argue that qualia are not a meaningful concept. Some philosophers, notably Colin McGinn, believe that the physical process causing consciousness to happen will never be understood, a position known as " new mysterianism." They do not deny that most other aspects of consciousness are subject to scientific investigation but they argue that qualia will never be explained. ![]() Consciousness Īccording to Thomas Nagel in his paper " What Is It Like to Be a Bat?", consciousness can refer to the ability of any entity to have subjective perceptual experiences, or as some philosophers refer to them, " qualia"-in other words, the ability to have states that it feels like something to be in. These further features of consciousness may not be necessary for sentience, which is the capacity to feel sensations and emotions. According to Antonio Damasio, sentience is a minimalistic way of defining consciousness, which otherwise commonly and collectively describes sentience plus further features of the mind and consciousness, such as creativity, intelligence, sapience, self-awareness, and intentionality (the ability to have thoughts about something). ![]() In philosophy, different authors draw different distinctions between consciousness and sentience. 3 Animal welfare, rights, and sentience.1.3 Empirical data on conditioned reflex precision.1.2 Recognition paradox and relation to sapience. 4/11/2023 0 Comments Aqua illuminations hydra 26With HD, when you turn down the intensity of one color, you can use that available power to increase color intensities you desire.Ī dedicated moonlight LED and channel has been added in the new Prime 16HD, Prime Freshwater, Hydra 32HD and Hydra 64HD fixtures which simulates natural lunar color and intensity.Įach tank has a dashboard with easy-to-access quick keys for turning your lights on/off or changing the mode Plenty of growing power along with HD functionality makes the Hydra one of the most powerful LEDs AI has ever made. Brilliantly simple and brighter than brightĬontinued development has seen AI achieve the perfect colour spectrum for the reef aquarium straight from the box, with strong emphasis on the crisp blue white hue that serious hobbyists in Europe demand.įrom this perfect starting point the lights can be controlled to an almost infinite range of colours that can be varied continuously throughout the day. This unique innovation in aquarium lighting allows you to direct power from the LED colours you have turned down to use with the colours you want to turn up, providing you with access to the maximum power output of your light, regardless of your choice of spectrum and creating the most vivid colours in your tank you have ever seen.īy coupling HD technology with custom almost optically perfect, 80 degree, colour blending lenses we can direct all of the light into the aquarium, exactly where it is needed, providing optimum PAR with minimal light loss or annoying glare for the observer. When Hyperdrive™ HD Technology was introduced with the previous generation of AI lights it revolutionised the way that the LED colours could be controlled, bringing more power and color where you want it, for your corals and fishes, plus the freedom to use your smartphone or computer as a controller. This allows for independent moonlighting programmes that will deliver the desired aesthetic without needing to be a part of your primary schedule or risking over exposure for your livestock. LED placement and lens geometry blend the light from the clusters so that colour separation is further reduced.Ī dedicated moonlight LED and channel has been added in the new Prime 16HD, Prime Freshwater, Hydra 32HD and Hydra 64HD fixtures. The incorporation of more LEDS results in a more complete full spectrum and TIR lenses which shape the light to its most efficient and effective result in both more colour POP as well as a slightly wider output area. Output in terms of PAR, color mixing and spread are all improved with the new fixtures. Water resistance is a major benefit in aquarium lighting, and while the new Prime and Hydras are not waterproof, design improvements should make them more resilient to accidental splashing and environmental moisture. Efficiency improvements reduce the demands for active cooling resulting in longer component life, and by reducing the profile depth has enhanced the presence of the light over the aquarium. Redesigning the plastics in the Prime and Hydra line-up has resulted in two major benefits: greater efficiency and better aesthetics. Easier and Faster to Connect to MyAi app.They have been perfecting this design for years and every detail has been meticulously attended to and we think you’ll love the end result. As time goes on, they continue to shape their lighting products to meet and exceed the expectations of the community, for better performance, greater reliability and improved ease of use, understanding that to be your first choice for aquarium lighting they must always be delivering the best value in performance, features and support. Vibrance is improved with deeper blues and brighter whites, your corals will pop like never before.ĪI has always listened to the feedback from hobbyist, retailers and aquaculture facilities. With over 20% more LEDs, the Aquaillumination flagship lights just got more power to grow coral, making them eye-blindingly bright. Introducing the HYDRA 64HD, HYDRA 32HD and PRIME 16HD, with even more LED’s better colour mixing, wider spread, more colour, more compact, more water resistant, and more refined, all without sacrificing anything that made the 52HD, 26HD and PRIME HD great. ![]() ![]() More LEDs, More Power, More Colour and More Refined 4/11/2023 0 Comments Shade 3d basic![]() The second is the angle from the XY plane (the vertical angle). The first angle is the rotation from the X axis (the horizontal angle). As you can see, you define a view by specifying two angles. The Viewpoint Presets dialogue box is illustrated on the right. As you probably recognise from the command name it is a dialogue box driven command. It is, however, buried two layers deep in the pull-down menu so it's often quicker simply to type itĪt the keyboard, since there is no toolbar button. There are a number of ways to get an axonometric view of your AutoCAD drawing but the DDVPOINT command is probably the easiest and quickest to use. You can use this command to get an axonometric view of your drawing. How to use the 3DFACE and SHADE commands. Using this tutorial you will learn how to give objects a thickness, how to move them vertically, how to view your 3D creations and With a combination of the MOVE and Properties commands you can quickly create simple 3D drawings. ![]() ![]() All objects can be given an elevation by moving them in the Z direction using the MOVE command. Although objects with a thickness can be said to be extruded, this should not be confused with the EXTRUDE command which creates solid extrusions giving an object thickness produces a surface extrusion. Most 2D objects can be given a thickness using the thickness option in the Properties ( DDCHPROP) command. Although AutoCAD has a number of commands for creating special 3D objects, a lot can be achieved by changing the properties of basic 2D objects like polylines. 4/11/2023 0 Comments Fastest wav to flac converterStep 4 - Use Quick Convert or a Custom Conversion Configurationįrom the 'Convert' drop down menu you have the option of using the 'Quick Convert' feature to speed up the process, or you can click on the three dots at the bottom of the menu to set up a custom configuration. Note: You can also select multiple items for conversion by holding the 'Ctrl' key while clicking on the files you'd like to convert. Right-click on your selection to bring up the context menu and then mouse over the 'Convert' menu. Now that that you've loaded your songs into the Foobar2000 playlist window you can left-click on file you'd like to convert into other formats. Double-click the desired selections to add them to the playlist or add multiple files by holding the 'Ctrl' key while single-clicking each file. Then, click 'Add files' and browse to the files of your choice. Start by clicking on the 'File' menu in the top right corner. Once you have downloaded the appropriate codec you'll need to add the song(s) that you'd like to convert to the Foobar2000 playlist. Note: Make sure you remember where these files are saved on your computer, as you'll need to point Foobar2000 to the file destination to facilitate the conversion process – we'll cover that more in the final section of this tutorial. wav), as converting an MP3 or OGG to FLAC will not improve the quality, it will only make the file larger. It is important to note that converting to FLAC is only a good idea if the file is uncompressed (i.e. ![]() FLAC (Free Lossless Audio Codec) instead, as the resulting file will be of the same playback quality but much smaller – you can download the FLAC codec here. wav files you may want to consider converting them to. An alternative to MP3 that offers a much higher sound quality with similar disk space consumption is the OGG Vorbis - download the OGG codec here. MP3 then you'll need to download the LAME MP3 encoder binaries from this page. If you're going to be converting files to. Step 1 – Download the Appropriate Encoder Files However, converting audio files isn't always a self-explanatory process, so we've created the following tutorial to show you how to convert audio files to different formats using Foobar2000: Converting audio files into MP3, FLAC, WAV or other formats using this software is a great way to save disk space, improve playback quality, and make your songs compatible with all devices. with QT ending support and my andoid device not supporting alac i decided to convert m4a files over i did the alac first, then i did the low res aac/m4a once i realised this I used timestamp to back highlight 100's and added a custom 3 field of "low res" so that i know that the source file could have been better now some of these files meet my >960kps hi res minimum auto playlist threshold.Īnd auto playlist of this field reveals i have 831 files taking up 25.6.Foobar2000 is a freeware audio player equipped with a robust interface that includes comprehensive file conversion features. On the off topic low res yeah i don't Fully understand the aac/m4a files conversion but compared to alac files conversion these files seem to be similar in size to resulting flac but the low res files jumped in size and bitrate dramaticly I converted several hundred 960kbps (probably better to use >1250kps) in auto playlists to section out hi res files as metadata from hi res rarely contains bit depth field. I droped the 4 example wav's in that video into a gdrive. I did a video screen recording with commentary to better illustrate my problem. The hi res files convert are about the same size and bit rate but the low res convert quadrupled in size ![]() Q) In low res <320 aac/m4a VBR files on the same setting but selecting 16 instead of 24 this has shot up the size of the files like from 8mb to 38mb and the 256kb files are now towards 1000kbps is this an expected result? It convert a bunch of m4a files without issue (qt player installed in win10) some of these where hi res (>1200-6000 kbps). Which it obvioulsy just did because your playing it! Retrying convert, yields the same result with a restart of the track playing.įollowed by a Error box center of the screen."there was a problem decoding converting the folowing files"ĭetailing the item and problem columns with the message mediamonkey is unable to decode this format. (i verifiied the the root the dll is there.)Īlso right after it fails it plays the file which i can hear through headphones which i didn't ask it too. ![]() they are being directed to a different location not overwriting under the convert format/settingsĬ:\Users\murdi\OneDrive\MediaMonkey 5\MediaMonkey 5\Plugins/in_wav.dll As a test i wanted to convert a small no. 4/11/2023 0 Comments Movies like the raid![]() However, the emphasis on the preceding omens highlights the significance of the raid from the Anglo-Saxon perspective.Īlcuin termed the event an “unprecedented calamity,” as he described the church as “spattered with the blood of the priests of God, despoiled of all its ornaments.” He went on to say the pagans “trampled on the bodies of saints in the temple of God, like dung in the street.” The legacy of Lindisfarne The written description of the attack itself is very brief.Īll we know is that the church was destroyed, goods were stolen and blood was shed. It's interesting to note that despite the January date given in the Chronicle, the real date is commonly believed to have been June. Given the earlier raids elsewhere in the British Isles, the sight of an approaching longship would surely have caused panic and instigated preparations. Recent experiments have shown that an approaching longship could have been sighted from Lindisfarne with one-hour's warning, but those at the monastery were taken completely by surprise. It is certainly believed that the Viking longships arrived during stormy weather, or at least not on a clear day. A great famine immediately followed these signs, and a little after that in the same year on 8 January the raiding of heathen men miserably devastated God’s church in Lindisfarne island by looting and slaughter.” Here terrible portents came about over the land of Northumbria, and miserably frightened the people: these were period flashes of lightning, and fiery dragons were seen flying in the air. That's because in Alcuin’s letter to Higbald, he writes that the raid was a product of, “a voyage not thought possible.” We know that people from Denmark had already been to the British Isles, so the implication is that the Lindisfarne crews travelled from much farther away. It it believed that earlier raids may have been made from what we know today as Denmark, but the raid on Lindisdarne could have been conducted by raiders from what we know of today as Norway, or Denmark. Wait, didn't the Chronicle reference Danish people? As told by a Viking researcher on the Life in Norway Show, Danes or Danish was a catch-call term and not necessarily used to refer to people from what we now know as Denmark. Lindisfarne, also known as the “Holy Island” was described by the monk Alcuin as “a place more sacred than any in Britain.” Lindisfarne priory Where did the Lindisfarne Vikings come from? One of the reasons the Lindisfarne raid is considered the start of the Viking Age is the major impact it had upon the Christian world in Britain and beyond. Gifts were given from royal figures and at the time of the raid, Lindisfarne likely held many riches including precious liturgical objects. With this increasing importance came increasing wealth and power. Following the death of the healer Cuthbert, many miracles were reported at his shrine. ![]() Cuthbert, appointed bishop of Lindisfarne in 685, it soon became a place of pilgrimage for believers. These were the first ships of the Danish men that sought the land of the English nation.” The importance of LindisfarneĮstablished in the mid-7th century, the monastery and bishopric at Lindisfarne grew to become the became the centre of a highly successful conversion mission.Īs the monastery held the relics of St. ![]() Reve then rode thereto and would drive them to the king’s town for he knew not what they were, and there was he slain. And in his days came first three ships of the Northmen from the land of robbers. This year King Bertric took Edburga the daughter of Offa to wife. In fact, England was targeted six years before, as recorded in the Anglo-Saxon Chronicle: Before the raidĪs mentioned before, the Lindisfarne raid was not the first time people in the British Isles encountered the seafaring Northmen. With that mind, read on for the full, fascinating story about the Viking raid on Lindisfarne. This was a reply to the original letter from Higbald to Alcuin, which likely contained many details of the raid. Two leading historical sources include excerpts from the Anglo-Saxon Chronicle, and a letter from the monk Alcuin to Bishop Higbald. This is why we are able to talk with greater confidence about Lindisfarne than many other elements of the Viking Age. However, we do have written historical records from the Lindisfarne, from the perspective of the Northumbrians. 4/11/2023 0 Comments Xmind pro 8 discount![]() Start to Start, Task A cann't be started untill Task B is started. Finish to Finish, Task A cann't be finished untill Task B is finished. Beautiful and easy to use XMind mind mapping tool. Desktop-class mind mapping graphics engine (Snowbrush): ensure a fast and powerful mind mapping experience as in the desktop The above Xmind 8 Pro coupons are so far the top online. CouponAnnie can help you save big thanks to the 12 active coupons regarding Xmind 8 Pro. But customers may need to use powerful features such as the Brainstorming mode, the Gantt chart, the Presentation, more exporting options and so on, then an XMind 8 Pro license key is required.There are now 1 discount code, 11 deal, and 0 free shipping coupon. After activating the free version with an XMind 8 Pro license key, customers will be using the Pro version.After adding all task details in the TaskInfo view, you can navigate them in the Gannt Chart view. ![]() Please select 'View - Show Gantt Chart' from menu.Build ID: R3.7.4.50.
4/11/2023 0 Comments Tux paint to play online![]() To open Tux Typing go to "Application -> Education ->Tux Typing". A cartoon version of Tux,appears at the bottom to give tips, hints and information. ![]() Once your download these files, copy that to your hard drive's Applications folder. Fun sound effects are played when tools are selected and used.Tux Paint is available in over 70 languages, features 250 stock images to paste into pictures, and can easily be customized by teachers and parents to fit the needs of a particular child. To download the Tux Typing for MAC OS you can click this link. Fun and easy-to-use, Tux Paint features a host of funny sound effects and a likable cartoon mascot who can guide a child through the drawing process.Follow the instructions and finish the installation.Go to the Downloaded folder and double click on that to install it to your system.To download the Tux Typing for Windows OS you can click this link.In the terminal window, type below command and press enter to start the installation by providing your machine password:.Tux Typing is a free and open source typing tutor created especially for new computer learners. Tux Typing can be used by children and adults alike for developing this skill. Open terminal by clicking "Applications -> System Tools -> Terminal" or through Keyboard shortcut Ctrl+Alt+T Tux Typing is a free and open source application for supporting basic digital literacy by getting familiar with the keyboard as a method of input.If you would like to install through the terminal follow these steps below:.In case you do not find it on your computer, you can install by typing Tux Typing on top search bar in Software Centre.The application is part of the Ubuntu custom distribution.It features several different types of game play, at a variety of difficulty levels. Tux Typing is a free and open source typing tutor created especially for children. It is designed to be fun and to improve words per minute speed of typists. The application includes two video game-style activities for younger players and finger lessons for experienced users. Tux Typing is a free and open source typing tutor created especially for new computer learners.įamiliarity with keyboard input is important for creating with ICT. Tux Typing is a free and open source application for supporting basic digital literacy by getting familiar with the keyboard as a method of input. Introduction Basic information ICT Competency 2.1 Starting typing practice on Tux Typing. 4/11/2023 0 Comments Screen tunnel![]() Issues are rare, but we take pride in doing everything in our power to keep our ROQ partners up and running. If your press isn't printing, that's no good for you or us. The offense pulls both LG/LT to slow down second-level defensive pursuit to the screen. Most replacement parts are stocked locally here in the US by Ryonet or can be found at many nationwide industrial supply companies. Houston motions to a balanced set and then runs a boundary tunnel screen off of a Counter look in the backfield. If something goes wrong we've got you covered at no cost for 3 whole years. In a competitive market such as the automatic press industry, this warranty is simply unheard of. 24/7 Toll-Free Support Line or Skype for diagnosing and resolving issues remote.Parts that fail due to normal wear-and-tear - and expendable parts such as platens, squeegee blades, backup batteries, motor brushes, filters, fuses, bulbs and glass - are excluded.Today, we confidently offer the industry's best automatic press warranty and boast a network of technicians with customer service that is second to none. At Ryonet, this is our favorite topic of discussion as these are the same concerns we once had when deciding to switch our automatic equipment manufacturer to ROQ. ![]() Stand out from the crowd and enhance your publications for less with a purchase from Alibaba's extensive wholesale post press equipment store.Like many that are exploring the possibility of an automatic machine for their shop, one major concern is warranty and service. That way, you can quickly supply your print shop with all of the tools required to publish unforgettable literature. Pick the right production capacity, power rating and size, and choose printing equipment to handle specific paper types. Search for folder gluers, binders, collators and curing machines and browse listings with comprehensive spec sheets attached. When you need a new tunnel dryer for screen printing, finding the right product is simple. And there are even specialist post-print machines to dry bottle labels. That's ideal for children's literature printers and anyone who prints glossy publications for business marketing. Paper collators can facilitate easy binding by bringing every page together after printing, while standard glue binding machines can handle large quantities of books and magazines. In some cases, UV LED curing machines will make a difference, making images stand out and allowing every color to shine. You can pick up hardcover binders and box makers for hardcover books - a great option for boutique publishers and B2B printers who want to make a splash. Some of our wholesale post press equipment is intended to help book manufacturers create bindings that suit their texts. There's a tunnel dryer for screen printing for everyone at Alibaba. Every post-printing machine is here, letting you create documents and images with a real wow factor. If you need a new tunnel dryer for screen printing for your printing operation, you've come to the right place. Play Tunnel Rush to dodge barriers using just your wits and your keyboard. Each Tunnel Rush level drops you into a whirling kaleidoscope of hazards and 3D tunnels. Blaze your way through caves and tunnels. Prints need to be mounted or bound, and integrated into products that are ready for general consumption. Tunnel Rush Unblocked is the ultimate 3D single-player experience. At that stage, the production process is far from over. Post press equipment refers to the devices we use after graphic or text printing has concluded. Create stunning photo books and attention grabbing magazines with the post press equipment available from. |
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